Drug Use and Its Consequences Increase Among Middle-Aged and Older Adults
The spread of marijuana use and the opioid epidemic over the past 10 years have affected middle-aged and older Americans. In addition, prescription opioid and benzodiazepine misuse increased older adults’ risk of suici…
Methadone Maintenance Treatment During Incarceration Has Long-Term Benefits
Prisoners who received methadone maintenance treatment (MMT) during incarceration were more likely than prisoners who did not receive MMT to engage in the treatment after being released.
Interim Buprenorphine Alleviates Psychiatric Symptoms in Waitlisted OUD Patients
Interim treatment with buprenorphine significantly improved the psychiatric symptoms of people awaiting comprehensive treatment for opioid use disorder (OUD). Buprenorphine treatment, even without concurrent psychosocial cou…
A Promising Alternative to Opioid Pain Medications
New Studies Clarify Risk Factors for Neonatal Abstinence Syndrome
A recent NIDA-sponsored study found higher rates of NAS among males than among females. A second study found that, among infants whose mothers were treated with buprenorphine while pregnant, NAS was more severe among those w…
Prescription Opioid Misuse Treatment Leverages Mindfulness To Amplify Natural Rewards
As Opioid Use Disorders Increased, Prescriptions for Treatment Did Not Keep Pace
Several effective medications are now available for treating opioid use disorder but many patients who could benefit do not receive them. Some patients who receive the medications face challenges to staying in treatment.
In Animals, Opioid Combination Shows Promise for Safer Pain Relief
In rats, the combination treatment of oxycodone/nalfurafine had lower levels of abuse liability and produced less respiratory depression than oxycodone alone.
Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients
Among patients with chronic pain, those who reported less ability to tolerate physical or emotional distress were more likely to misuse opioid analgesics.
Deep Brain Stimulation Attenuates Rats’ Responses to Heroin
High-frequency electrical stimulation of neurons deep in the brain can reduce rats’ relapse-like behavior and motivation to take heroin. The finding strengthens hope that deep brain stimulation might offer a new treatmen…
Opioid Agonist Treatment Reduces Societal Costs of Crime
Patients who initiate time-unlimited opioid-agonist therapy will generate lower average total crime-related costs over the next 6 months than patients who initiate a 21-day detoxification regimen.
Variation in the Gene for the μ-Opioid Receptor May Influence Responses to Methadone
A single nucleotide polymorphism in the messenger RNA of the µ-opioid receptor gene was associated with patients’ responses to methadone treatment for opioid dependence.
Nonmedical Opioid and Heroin Use Among High School Seniors
This study analyzed the use of use of nonmedical opioids and heroin use among 68,000 high-school seniors participating in the NIDA-funded Monitoring the Future Study between 2009 and 2013.
Buprenorphine Benefits Waitlisted Seekers of Opioid Treatment
In two pilot clinical trials, buprenorphine helped participants reduce their illicit opioid use and injection drug use while awaiting admission to a methadone or buprenorphine treatment program. Researchers minimized the risks…
Promising Advances in the Search for Safer Opioids
New studies show that two novel compounds powerfully suppressed animals’ pain responses, while producing little or none of the respiratory depression and liability for misuse and abuse associated with morphine and othe…
Messages Shore Up Support for Making Life-Saving Anti-Overdose Medication Widely Available
Public health messages can increase public approval for making naloxone legally available to friends and relatives of opioid users to administer if an overdose occurs.
Study Links Medical Marijuana Dispensaries to Reduced Mortality From Opioid Overdose
Legally protected marijuana dispensaries (LMDs) were associated with lower rates of dependence on prescription opioids, and deaths due to opioid overdose, than would have been expected based on prior trends. However, LMDs al…
Dual Regimen Aims To Shorten Medication-Assisted Therapy
Treatment that combines use of Bp/Nx and memantine may enable young adults addicted to opioids establish lasting abstinence after a relatively brief course of medication-assisted therapy, a pilot trial suggests.
ED-Initiated Buprenorphine Outperforms Referral or SBIRT for ED Patients With Opioid Addiction
Emergency department visits present prime opportunities to identify people with opioid addiction and provide them with onsite initiation of treatment with buprenorphine/naloxone.
Digital Addiction Therapies Affirm Promise in Replication and Large Trial
Two computerized programs improved outcomes when they were used to supplement or partially replace in-person behavioral therapy for drug addiction in recent NIDA-sponsored trials.
Patients Addicted to Opioid Painkillers Achieve Good Results With Outpatient Detoxification
A significant portion of individuals who are addicted to opioid painkillers may initiate and maintain abstinence with a brief but intensive outpatient detoxification treatment followed by opioid antagonist therapy using naltre…